Untargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Food Control Year : 2019

Untargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea

Grégoire Delaporte
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  • IdHAL : gdelaporte
Mathieu Cladière

Abstract

This study aims at assessing the capability of comparing and combining different instrumental platforms in an untargeted approach with a view of detecting chemical contaminants in food matrices at low levels. A strategy based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) and chemometrics has been applied on two different complex food contamination scenarios, with tea as study product. The first scenario aimed at mimic the presence of a dozen of contaminants at levels just above regulatory limits (i.e. 10 and 30 mu g/kg); the second scenario, more complex, aimed at simulate the presence of several different contaminations at levels close to regulatory limits (10 mu g/kg) in different samples. This work was carried on two LC-HRMS platforms (with respectively ToF and Orbitrap mass analyzer technologies), and a highly automated data treatment workflow was implemented to deal with data acquired on both platforms. The untargeted approach performed well on all scenarios (even the most complex) and analytical platforms. Performance comparison between LC-HAMS technologies was made possible thanks to a vendor-neutral data treatment process.
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Dates and versions

hal-02625931 , version 1 (09-05-2022)

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Grégoire Delaporte, Mathieu Cladière, Valérie V. Camel. Untargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea. Food Control, 2019, 98, pp.510-519. ⟨10.1016/j.foodcont.2018.12.004⟩. ⟨hal-02625931⟩
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