Microbiota-gut brain axis involvement in neuropsychiatric disorders
Luigi Francesco Iannone
(1)
,
Alberto Preda
(2)
,
Hervé H Blottiere
(3)
,
Gerard Clarke
(4)
,
Diego Albani
(5)
,
Vincenzo Belcastro
(6)
,
Marco Carotenuto
(7)
,
Anna Cattaneo
(5, 8)
,
Rita Citraro
(1)
,
Cinzia Ferraris
(9)
,
Francesca Ronchi
(10)
,
Gaia Luongo
(11)
,
Elisa Santocchi
(12)
,
Letizia Guiducci
(13)
,
Pietro Baldelli
(2)
,
Paola Iannetti
(14)
,
Sigrid Pedersen
(15)
,
Andrea Petretto
(16)
,
Stefania Provasi
(5)
,
Kaja Selmer
(15)
,
Alberto Spalice
(2)
,
Anna Tagliabue
(8)
,
Alberto Verrotti
(17)
,
Nicola Segata
(18)
,
Jakob Zimmermann
(10)
,
Carlo Minetti
(2)
,
Paolo Mainardi
(19)
,
Carmen Giordano
(20)
,
Sanjay Sisodiya
(21)
,
Federico Zara
(16)
,
Emilio Russo
(1)
,
Pasquale Striano
(2)
1
University of Catanzaro
2 UniGe - Università degli studi di Genova = University of Genoa
3 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
4 UCC - University College Cork
5 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
6 Saint Anna Hospital
7 Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
8 King's College
9 UNIPV - Università degli Studi di Pavia = University of Pavia
10 UNIBE - Universität Bern = University of Bern = Université de Berne
11 Ordine dei Tecnologi Alimentari Campania e Lazio
12 Stella Maris Foundation
13 Institute of Clinical Physiology
14 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
15 Oslo University Hospital [Oslo]
16 Istituto Giannina Gaslini
17 University of Laquila
18 UNITN - Università degli Studi di Trento = University of Trento
19 Kolfarma SRL
20 CMIC - Department of Chemistry, Materials and Chemical Engineering "Giulio Natta"
21 Department of Clinical and Experimental Epilepsy
2 UniGe - Università degli studi di Genova = University of Genoa
3 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
4 UCC - University College Cork
5 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
6 Saint Anna Hospital
7 Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
8 King's College
9 UNIPV - Università degli Studi di Pavia = University of Pavia
10 UNIBE - Universität Bern = University of Bern = Université de Berne
11 Ordine dei Tecnologi Alimentari Campania e Lazio
12 Stella Maris Foundation
13 Institute of Clinical Physiology
14 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
15 Oslo University Hospital [Oslo]
16 Istituto Giannina Gaslini
17 University of Laquila
18 UNITN - Università degli Studi di Trento = University of Trento
19 Kolfarma SRL
20 CMIC - Department of Chemistry, Materials and Chemical Engineering "Giulio Natta"
21 Department of Clinical and Experimental Epilepsy
Hervé H Blottiere
- Fonction : Auteur
- PersonId : 747227
- IdHAL : herve-blottiere
- ORCID : 0000-0002-8390-0607
- IdRef : 076955648
Diego Albani
- Fonction : Auteur
- PersonId : 785158
- ORCID : 0000-0002-7050-6723
Nicola Segata
- Fonction : Auteur
- PersonId : 793997
- ORCID : 0000-0002-1583-5794
Pasquale Striano
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- Fonction : Auteur correspondant
- PersonId : 769112
- ORCID : 0000-0002-6065-1476
- IdRef : 200024612
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Résumé
Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene-environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments. Areas covered: To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration, and combination of data from existing gut microbiome/microbiota projects and appropriate other International '-Omics' studies. The authors also evaluated the new technological advances to investigate and modulate, through nutritional and other interventions, the gut microbiota. Expert opinion: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved.