Skip to Main content Skip to Navigation
Journal articles

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

Abstract : Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert structural components of brain, largely important for the formation of cellular membranes. Over the past 10 years, a host of bioactive lipid mediators that are enzymatically derived from arachidonic acid, the main n-6 PUFA, and docosahexaenoic acid, the main n-3 PUFA in the brain, known to regulate peripheral immune function, have been detected in the brain and shown to regulate microglia activation. Recent advances have focused on how PUFA regulate the molecular signaling of microglia, especially in the context of neuroinflammation and behavior. Several active drugs regulate brain lipid signaling and provide proof of concept for targeting the brain. Because brain lipid metabolism relies on a complex integration of diet, peripheral metabolism, including the liver and blood, which supply the brain with PUFAs that can be altered by genetics, sex, and aging, there are many pathways that can be disrupted, leading to altered brain lipid homeostasis. Brain lipid signaling pathways are altered in neurologic disorders and may be viable targets for the development of novel therapeutics. In this study, we discuss in particular how n-3 PUFAs and their metabolites regulate microglia phenotype and function to exert their anti-inflammatory and proresolving activities in the brain.
Complete list of metadata

https://hal.inrae.fr/hal-02629278
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Wednesday, May 27, 2020 - 3:02:14 AM
Last modification on : Tuesday, July 6, 2021 - 2:54:03 PM

Links full text

Identifiers

Collections

Citation

Sophie Laye, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet. Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology. Pharmacological Reviews, American Society for Pharmacology and Experimental Therapeutics, 2018, 70 (1), pp.12-38. ⟨10.1124/pr.117.014092⟩. ⟨hal-02629278⟩

Share

Metrics

Record views

16