Ruminant livestock systems are significant sources of greenhouse gases (GHG). Livestock farming in regions with extreme climatic events have to face both scarcity and variability in feed resources. Herd mobility is a known major adaptation strategy to address seasonal availability of forage resources: it allows an increase in herd size, thereby improving labor productivity. The present study quantifies enteric methane (CH4) emissions from French Mediterranean sheep farming systems, focusing on the use of diversified pastoral feed resources, and developing a calculator (Diversity of feed REsources and Enteric Methane emissions, DREEM). The DREEM calculator was developed to estimate at the animal level enteric CH4 emissions (g/day) from empirical equations and be subsequently integrated, as a sub-table, into an economic and GHG (kg/year) balance model (Outil de Simulation du TRoupeau ovin ALaitant, OSTRAL) at the whole farm level. Several equations were taken from the literature to estimate enteric CH4 emissions in DREEM calculator. Nature of forage and feed, animal feeding levels and performance were referenced according to the animal feeding system and tables in France and taking into account the French Mediterranean area studied. DREEM was used to estimate enteric CH4 emissions from four sheep farming systems covering the main contrasting mobility and situations, from sedentary to highly mobile pastoral systems, in the French Mediterranean area. At the individual level, enteric CH4 emissions (g/ day) of ewes in the sedentary system were slightly higher than those of ewes in other systems. These differences were due mainly to differences in animal feeding level (intake / body weight) and feed resources characteristics. Overall, enteric CH4 emissions of ewes and rams were slightly lower than French national inventory estimates. When enteric CH4 emissions of lambs were expressed in g/kg of carcass, were lower in the less pastoral farming systems than in the other systems, because lambs' average daily gains were higher. In double transhuming farming systems, lambs late slaughtering age led to lamb's CH4 contribution of 15% vs 2-5% in the other systems. Flock management, which depends on land use and ownership, greatly contributed to these results.