Futures Challenges in Thyroid Hormone Signaling Research - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Frontiers in Endocrinology Year : 2016

Futures Challenges in Thyroid Hormone Signaling Research

Abstract

The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research.
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hal-02635655 , version 1 (27-05-2020)

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Frederic Flamant. Futures Challenges in Thyroid Hormone Signaling Research. Frontiers in Endocrinology, 2016, 7, ⟨10.3389/fendo.2016.00058⟩. ⟨hal-02635655⟩
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