Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Brain, Behavior, and Immunity Year : 2016

Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro

Abstract

Sustained inflammation in the brain together with microglia activation can lead to neuronal damage. Hence limiting brain inflammation and activation of microglia is a real therapeutic strategy for inflammatory disease. Resolvin D1 (RvD1) and resolvin E1 (RvE1) derived from n-3 long chain polyunsaturated fatty acids are promising therapeutic compounds since they actively turn off the systemic inflammatory response. We thus evaluated the anti-inflammatory activities of RvD1 and RvE1 in microglia cells in vitro. BV2 cells were pre-incubated with RvD1 or RvE1 before lipopolysaccharide (LPS) treatment. RvD1 and RvE1 both decreased LPS-induced proinflammatory cytokines (TNF-α, IL-6 and IL-1β) gene expression, suggesting their proresolutive activity in microglia. However, the mechanisms involved are distinct as RvE1 regulates NFκB signaling pathway and RvD1 regulates miRNAs expression. Overall, our findings support that pro-resolving lipids are involved in the resolution of brain inflammation and can be considered as promising therapeutic agents for brain inflammation.
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Dates and versions

hal-02636094 , version 1 (27-05-2020)

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Charlotte Rey, Agnes Nadjar, B. Buaud, C. Vaysse, Agnès Aubert, et al.. Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro. Brain, Behavior, and Immunity, 2016, 55, pp.249-259. ⟨10.1016/j.bbi.2015.12.013⟩. ⟨hal-02636094⟩
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