Skip to Main content Skip to Navigation
Journal articles

Postprandial regulation of growth and metabolism related factors in zebrafish

Abstract : Zebrafish (Danio rerio) have been proposed as a possible model organism for nutritional physiology. However, this potential has not yet been realized and studies on the field remain scarce. In this work, we investigated in this species the effect of a single meal as well as that of an increase in the ratio of dietary carbohydrates/proteins on the postprandial expression of several hepatic and muscle metabolism-related genes and proteins. Fish were fed once either a commercial diet (experiment 1) or one of two experimental diets (experiment 2) containing different protein and carbohydrate levels after 72 h of starvation. Refeeding induced the postprandial expression of genes of glycolysis (GK, HK1) and lipogenesis (FAS, G6PDH, ACCa) and inhibited those of gluconeogenesis (cPEPCK) and beta-oxidation (CPT1b) in the viscera. In the muscle, refeeding increased transcript levels of myogenesis (Myf5, Myogenin), inhibited those of Ub-proteasomal proteolytic system (Atrogin1, Murf1a, Murf1b), and induced the activation of key signaling factors of protein synthesis (Akt, 4EBP1, S6K1, S6). However, diet composition had a low impact on the studied factors. Together, these results highlight some specificity of the zebrafish metabolism and demonstrate the interest and the limits of this species as a model organism for nutritional physiology studies
Document type :
Journal articles
Complete list of metadata
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Friday, May 29, 2020 - 4:49:26 PM
Last modification on : Thursday, August 5, 2021 - 3:42:11 AM

Links full text




Iban Seiliez, Françoise Médale, Pierre Aguirre, Mélanie Larquier, Laura Lanneretonne, et al.. Postprandial regulation of growth and metabolism related factors in zebrafish. Zebrafish, Mary Ann Liebert, 2013, 10 (2), pp.237-248. ⟨10.1089/zeb.2012.0835⟩. ⟨hal-02651550⟩



Record views