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Modèles animaux de retard de croissance intra-utérin d'origine vasculaire

Abstract : Placental insufficiencies can complicate up to 7% of all pregnancies. They can lead to intrauterine growth retardation (IUGR) and preeclampsia, and represent a major public health concern. The pathophysiology of these placental anomalies is not yet fully understood. For obvious ethical reasons, studies in pregnant women are limited to non-invasive techniques, such as ultrasound scans and maternal blood tests. Therefore, animal models of IUGR play an important role in the study of this condition. Because the models using maternal undernutrition to induce foetal IUGR are not as appropriate to mimic the vascular IUGR observed in developed countries, we describe the animal models of vascular IUGR used currently: models based on an application of stress to the mother, genetic models, and surgical models. Finally, we describe briefly the controlled hypoperfusion model in non-anaesthetized ewes, currently developed in our laboratory.
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https://hal.inrae.fr/hal-02658234
Contributor : Migration Prodinra <>
Submitted on : Saturday, May 30, 2020 - 11:54:13 AM
Last modification on : Thursday, August 5, 2021 - 3:48:58 AM

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Pascale Chavatte-Palmer, Olivier Morel, Frédéric Pachy, Vassilis Tsatsaris, Michel Bonneau. Modèles animaux de retard de croissance intra-utérin d'origine vasculaire. Bulletin de l'Académie Vétérinaire de France, Académie vétérinaire de France, 2008, 161 (5), pp.461-466. ⟨hal-02658234⟩

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