HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Effects of ovariectomy in prebubertal goats

Abstract : The objectives of this study were to determine the effects of ovariectomy on mammary gland development in prepubertal goats and to validate this model to study mammogenesis in young dairy ruminants. In this experiment, 3 months of aged goats were ovariectomized (ovx) while shammed goats played as surgery controls (sham). Thereafter, sham and ovx goats were slaughtered at 7 months of age to provide tissue for the assays. Results demonstrated that proliferation of mammary of mammary epithelial cells was significantly lower in ovariectomized goats compared to control goats. In ovx animal, epithelium structures were completely overstretched and epithelial ducts were undeveloped with limited branching whereas control animals had classical complex arborescent units with multiple round ductules and limited stroma. Concerning ER alpha (estrogen receptor alpha), PR (progesterone receptor) and P450 (aromatase) expression, results showed number of ER alpha, PR and P450 positive cells was higher in shammed goats compared to ovariectomized goats. All this results suggested that goat mammogenesis and ovarian control are similar to prepubertal heifers and that young goats are a good model to study mammary gland development in ruminants. In conclusion, we demonstrated that ovariectomy of prepubertal goats decreased proliferation of mammary epithelial cells with a profound alteration of cell adhesion molecules.
Document type :
Journal articles
Complete list of metadata

Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Sunday, May 31, 2020 - 1:24:29 AM
Last modification on : Wednesday, April 6, 2022 - 4:08:20 PM


  • HAL Id : hal-02662849, version 1
  • PRODINRA : 34022
  • WOS : 000271599500017



Frederic Dessauge, Laurence Finot, Sandra Wiart, Jean Marc Aubry, S.E. Ellis. Effects of ovariectomy in prebubertal goats. Journal of Physiology and Pharmacology, Krakow Polish Physiological Society, 2009, 60, pp.127-133. ⟨hal-02662849⟩



Record views