A population of 122 recombinant inbred lines obtained by crossing a Charentais-type cultivar, Vedrantais, and the resistant Korean PI 161375 was evaluated for resistance to cucumber mosaic cucumovirus (CMV) in melon (Cucumis melo L.). Dates of appearance and intensity of symptoms were recorded upon infection with three CMV strains, two strains from Subgroup I (TL and P9), and one from Subgroup II (To 72). A saturated molecular map was constructed from the same population and was used for detecting quantitative trait loci (QTL). Seven genomic regions were found to carry factors for resistance to CMV. One of them, located in linkage group XII and accounting for a large amount of the phenotypic variation, is common to the three CMV strains. Other detected QTLs are strain-specific and are provided either by the resistant parental line or by the susceptible one.