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Impact of maternal hyperlipidic hypercholesterolemic diet on male reproductive organs and testosterone concentration in rabbits

Charlotte Dupont 1, 2 Delphine Ralliard-Rousseau 1 Anne Tarrade 1 C. Faure 2 Michele Dahirel 1 B. Sion 3 R. Levy 2 Pascale Chavatte Palmer 1
3 Pharmacologie fondamentale et clinique de la douleur
Neuro-Dol - Neuro-Dol, UdA - Université d'Auvergne - Clermont-Ferrand I, INSERM - Institut National de la Santé et de la Recherche Médicale : U766
Abstract : The concept of Developmental Origins of Health and Disease (DOHAD) has expanded for two decades. Many epidemiological studies and experiments in animal models have highlighted an increased risk of long-term metabolic and cardiovascular diseases in case of nutritional imbalance during pregnancy or gestation. Reproductive functions and fertility in adulthood may also be programmed during fetal devel- opment. The rabbit is a relevant model to assess effect of developmental programming on reproductive functions. In our laboratory, a model of female rabbits fed with a diet enriched 6% of soybean oil and 0.2% cholesterol (HH) before and during pregnancy induced an intrauter- ine growth retardation and a metabolic syndrome in offspring at adulthood. In this study, we studied the impact of HH diet, administered at 10 weeks of age and throughout the gestation and lactation, on male reproductive functions of rabbit offspring. Rabbits born from HH dams had significantly lighter testes (p< 0,05) and epididymes (p< 0,05) compared to rabbits born from control dams. Considering the relative weight, the difference remained significant (p< 0,05 et p< 0,01 respectively). The seminiferous epithelium height was comparable between the 2 groups. No significant differences in sperm concentration, sperm DNA integrity and sperm mem- brane composition were observed. Interestingly, plasma free testosterone concentrations were decreased in males born from HH dams (p=0.05) at 37 weeks of age. This study confirms the importance of maternal metabolic status and early environment for male reproductive organs development.
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https://hal.inrae.fr/hal-02741147
Déposant : Migration Prodinra <>
Soumis le : mercredi 3 juin 2020 - 00:41:41
Dernière modification le : jeudi 2 juillet 2020 - 15:12:52

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  • HAL Id : hal-02741147, version 1
  • PRODINRA : 256612

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Charlotte Dupont, Delphine Ralliard-Rousseau, Anne Tarrade, C. Faure, Michele Dahirel, et al.. Impact of maternal hyperlipidic hypercholesterolemic diet on male reproductive organs and testosterone concentration in rabbits. International conference on Developmental Origins of Adiposity and Long-Term Health, Mar 2014, Munich, Germany. 106 p., 2014, The power of programming 2014, International conference on Developmental Origins of Adiposity and long-term health, Programme and Abstracts. ⟨hal-02741147⟩

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