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Communication dans un congrès

Maternal exposure to diesel exhaust alters placental function and induces intergenerational effects in rabbits

Sarah Valentino 1, 2, 3 Anne Tarrade 1, 2, 3 Josiane Aioun 1, 2, 3 Eve Mourier 1, 2, 3 Christophe Richard 1, 2, 3 Michèle Dahirel 1, 2, 3 Delphine Rousseau Ralliard 1, 2, 3 Natalie Fournier 4, 5 Marie-Christine Aubrière 1, 2, 3 Marie-Sylvie Lallemand 1, 2, 3 Sylvaine Camous 1, 2, 3 Marine Guinot 1, 2, 3 Madia Charlier 6 Etienne Aujean 6 Hala Al Adhami 1, 2, 3 Paul H. Fokkens 7 Lydiane Agier 8 John A. Boere 7 Flemming R. Cassee 7, 9 Rémy Slama 10 Pascale Chavatte Palmer 1, 2, 3
1 BDR - Biologie du Développement et Reproduction
2 Université Paris Saclay (COmUE)
3 Fondation PremUp
4 Groupe de Chimie Analytique de Paris-Sud
5 Laboratoire de Biochimie, UF Cardio-Vasculaire
6 GABI - Génétique Animale et Biologie Intégrative
7 Centre for Sustainability Environment and Health
8 U823, Epidemiologie Environnementale Appliquée à la Reproduction et la Santé Respiratoire
9 Institute of Risk Assessment Sciences
10 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
Abstract : Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to air- borne pollution, in particular diesel engine exhaust (DE), reduces birth weight. These effects depend on exposure duration, ges- tational window, and nanoparticle (NP) concentration. Our aim was to evaluate the effects of exposure to diluted DE on F0 on feto-placental development in a rabbit model in the F1 and F2 generations. Pregnant females were exposed to diluted (1 mg/m3), filtered DE (NP diameter ≈ 69 nm) or clean air (controls) for 2 h/day, 5 days/week by nose-only exposure (total exposure: 20 days in a 31-day gestation). DE exposure induced early signs of growth retarda- tion at mid gestation with decreased head length (p = 0.04) and umbilical pulse (p = 0.018). Near term, fetal head length (p = 0.029) and plasma insulin and IGF1 concentrations (p = 0.05 and p = 0.019) were reduced. Placental function was also affected, with reduced placental efficiency (fetal/placental weight) (p = 0.049), decreased placental blood flow (p = 0.009) and fetal vessel volume (p = 0.002). Non-aggregated and “fingerprint” NP were observed at various locations, in maternal blood space, in trophoblastic cells and in the fetal blood, demonstrating transplacental transfer. Adult female offspring were bred with control males. Although fetoplacental biometry was not affected near term, second generation fetal metabolism was modified by grand-dam exposure with decreased plasma cholesterol (p = 0.008) and increased triglyceride concentrations (p = 0.015). Repeated daily gestational exposure to DE at levels close to urban pollution can affect feto-placental development in the first and second generation.
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Communication dans un congrès
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https://hal.inrae.fr/hal-02742499
Déposant : Migration Prodinra <>
Soumis le : mercredi 3 juin 2020 - 04:14:47
Dernière modification le : mercredi 16 septembre 2020 - 17:18:26

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INRAE | INRA | U823 | AGROPARISTECH | UGA | UNIV-PARIS-SACLAY

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Sarah Valentino, Anne Tarrade, Josiane Aioun, Eve Mourier, Christophe Richard, et al.. Maternal exposure to diesel exhaust alters placental function and induces intergenerational effects in rabbits. 44. Annual Conference of the European Teratology Society, European Teratology Society (ETS). GBR., Sep 2016, Dublin, Ireland. 210 p., ⟨10.1016/j.reprotox.2016.06.054⟩. ⟨hal-02742499⟩

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