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Microbiote intestinal chez le porc : paramètres génétiques de sa composition et liens avec des caractères immunitaires

Abstract : Our objectives were to estimate genetic parameters of the gut microbiota composition in French Large White pigs, and to uncover co-variations between the abundances of microbial communities and immunity or growth parameters of the host. In the framework of the Sus-Flora project, we characterized the diversity of the faecal microbiota of 518 60 day-old piglets by sequencing a variable region of the ribosomal 16S gene. Our first results have shown that the genera Prevotella, followed by Oscillibacter, Dialister, Roseburia or Treponema are dominant in the porcine faecal microbiota. Heritability values ranging from 0.13 0.08 to 0.55 0.16 were estimated for the relative abundance of 19 of the most common bacterial genera, highlighting the contribution of the host genome to the shaping of the gut microbial ecosystem. Regularized canonical correlations and sparse Partial Least Squares analyses highlighted both positive and negative correlations between immunity traits (e.g. monocytes, eosinophils, platelets) and genera such as Prevotella, Roseburia and Dialister. The establishment of microbial diversity in the gut was assessed by following a subset of 31 piglets at 14, 36, 48, 60 and 70 days of age. We showed that the gut microbiota composition was stabilized after 36 days of age. In addition, a stratification of the 31 piglets in two groups was observed after weaning, suggesting the existence of enterotypes as observed in humans. These two enterotype-like clusters were primarily distinguished by the levels of unclassified Ruminococcaceae and Prevotella, respectively. These two enterotype-like clusters were also found in the cohort of 518 60 day-old piglets.
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https://hal.inrae.fr/hal-02742708
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Submitted on : Wednesday, June 3, 2020 - 4:40:58 AM
Last modification on : Wednesday, November 3, 2021 - 6:51:46 AM

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  • HAL Id : hal-02742708, version 1
  • PRODINRA : 353928

Citation

Jordi Estelle, Catherine Larzul, Nuria Mach, Florence Levenez, Yuliaxis Ramayo Caldas, et al.. Microbiote intestinal chez le porc : paramètres génétiques de sa composition et liens avec des caractères immunitaires. 48. Journées de la Recherche Porcine, Institut du Porc (IFIP). FRA., Feb 2016, Paris, France. ⟨hal-02742708⟩

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