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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Abstract : Mammary development and fonction was abnormal in exposed clams. The a!veolar lumina were characterized by a marked increase in fat globules number and volume (p< 0.05) . Total fatty acid (FA) content was increased (p< 0.05) in DE-exposed rabbit milk on days 2-4 of lactation, essentially due to higher medium-chain FA concentrations. Sex-specific responses to maternai exposure were observed in offspring after weaning. In-utero exposed males hacl metabolic disorders with increased blood pressure (p=0.058) , higher glycemia (p=0.019) , lower HDL-cholesterol (p=0.025) , reduced fat-to-bocly weight ratio (p=0.011) but in­ creased peri-renal fat mass (p=0.026). Females had only higher triglycerides (TG) compared to contrai offspring. Testicular and ovarian structure and fonction were analyzed by histology and immunohistochemistry, demonstrating no difference between groups. In contrast , there was more DN A fragmentation (p=0.0012) in epididymal sperm in the exposed group. Adult female offspring were bred with contrai males. Although fetoplacental biometry was not affected near term, 2nd generation fetal metabolism was modifiecl by grand-dam exposure with decreased plasma cholesterol (p=0.008) and increased TG concentrations (p=0.015). In conclusion, repeated gestational exposure to DE at levels close to urban pollution can affect feto-placental clevelopment and health over 2 generations.
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Submitted on : Wednesday, June 3, 2020 - 5:56:54 AM
Last modification on : Friday, August 5, 2022 - 2:38:10 PM


  • HAL Id : hal-02743432, version 1
  • PRODINRA : 382122


Sarah Valentino, Anne Couturier-Tarrade, Delphine Rousseau-Ralliard, Eve Mourier, Christophe Richard, et al.. Reproductive effects of gestational exposure to diesel exhaust in a rabbit model. 3. congrès de la SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Dec 2016, Paris, France. 84 p. ⟨hal-02743432⟩



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