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Conference papers

A periconceptional maternal hyperglycemia disrupts the feto-placental membrane fatty acid profiles in a rabbit model

Abstract : Type-1 diabetes (T1D) is caused by the reduction in pancreatic insulin secretion, inducing chronic hyperglycemia. Pre-gestational T1D increases the risk of miscarriage and congenital malformations and programs the offspring to develop metabolic syndrome at adult-hood. Management of maternal diabetes is essential during the gestation but could be highly important around the conception. The aim of this study was to explore the effects of maternal TD1 during the periconceptional period on feto-placental phenotype at 28dpc (term=31days), according to the sex of the conceptus. Diabetes was induced by Alloxan in dams 7 days before mating. Glycemia was maintained at 15-20mmol/L with exogenous insulin injections. At 4dpc, embryos were collected and transferred into non-diabetic recipients. At 28 dpc, control (C) and diabetic (D) fetuses were collected for biometric records and lipid analysis of feto-placental tissues by gas chromatography. Data were analyzed by principal component analyses. D-fetuses were growth retarded, hyperglycemic and dyslipidemic compared to C. A specific fatty acid signature was observed in fetal plasma. The composition of placental and fetal liver membranes differed according to maternal status and fetal sex. Tissues from D-fetuses contained significantly more omega-6 polyunsaturated fatty acids compared to C. No biochemical signature was observed in the immature fetal heart, but docosahexaenoic acid was decreased and linoleic acid increased in the cardiac membranes of D-fetuses, indicating a higher risk of ischemia. This study demonstrates that an exposure to high plasma glucose during the short peri-conceptional period reduces fetal growth and alters the lipid profiles in all fetal tissues.
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Submitted on : Wednesday, June 3, 2020 - 7:10:39 AM
Last modification on : Thursday, April 21, 2022 - 3:56:25 PM


  • HAL Id : hal-02744199, version 1
  • PRODINRA : 256621



Delphine Rousseau-Ralliard, Emilie Derisoud, Anne Couturier-Tarrade, Roselyne Brat, Audrey Rolland, et al.. A periconceptional maternal hyperglycemia disrupts the feto-placental membrane fatty acid profiles in a rabbit model. International conference on Developmental Origins of Adiposity and Long-Term Health, Early Nutrition Academy. DEU., Mar 2014, Munich, Germany. 106 p. ⟨hal-02744199⟩



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