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Communication dans un congrès

Genetic ablation of acetylcholinesterase alters muscle function in mice

Abstract : Although acetylcholinesterase (AChE) knockout mice survive, they have abnormal neuromuscular function. We analysed further the effects of the mutation on hind limb muscle contractile properties. Tibialis anterior muscle from AChE KO mice is unable to maintain tension during a short period of repetitive nerve stimulation (tetanic fade) and has an increased twitch tension in response to a single nerve electric stimulation. In response to direct muscle stimulation, we found that maximal velocity of shortening of soleus muscle is increased and maximum tetanic force is decreased in AchE KO mice versus control animals. As the contractile properties of the soleus muscle were altered by AChE ablation, our results suggest cellular and molecular changes in AChE ablated muscle containing both fast and slow Muscle fibres.
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Déposant : Migration Prodinra <>
Soumis le : jeudi 4 juin 2020 - 03:03:24
Dernière modification le : mercredi 26 août 2020 - 14:26:07




Audrey Vignaud, F. Fougerousse, E. Mouisel, Christelle Bertrand, Béatrice Bonafos, et al.. Genetic ablation of acetylcholinesterase alters muscle function in mice. 9. International Meeting on Cholinesterases, May 2007, Suzhou, China. ⟨10.1016/j.cbi.2008.04.035⟩. ⟨hal-02758076⟩



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