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Communication dans un congrès

AGFD 148-The strategy of alleviating mycotoxin impact on the animal: A comprehensive study of mycotoxin adsorption through the use of Saccharomyces cerevisiae cell wall

Abstract : A comprehensive study of the adsorption abilities of Saccharomyces cerevisiae cell wall components towards aflatoxin B1, deoxynivalenol, zearalenone, patulin and ochratoxin A was achieved in vitro. The comparison of several sources of yeast cell wall differing in their relative glucan/mannan/chitin showed a strong involvement in the adsorption process of the beta-D-glucan moiety, composed of linear chains of (1,3)-beta-D-glucans branched with (1,6)-beta-D-glucan side chains. Affinity rates varied widely between toxins due to their structural and physico-chemical disparities. The chemical interaction approached by molecular mechanics, NMR, X-ray structural data analysis, demonstrated the importance of the single and/or triple helix organization of beta-D-glucans. We emphasized that chemical interactions involved weak but multiple chemical hydrogen and van der Waals bonds leading to the chemical encagment of mycotoxins into the helix-shaped (1,3)-beta-D-glucan structure firmly stabilized by the (1,6)-beta-D-glucan side branching providing a high geometric complementarity's and stability to the overall system.
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Communication dans un congrès
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https://hal.inrae.fr/hal-02758338
Déposant : Migration Prodinra <>
Soumis le : jeudi 4 juin 2020 - 03:30:13
Dernière modification le : vendredi 12 juin 2020 - 10:43:26

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  • HAL Id : hal-02758338, version 1
  • PRODINRA : 219055
  • WOS : 000271775100206

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Alexandros Yiannikouris, Gérard Bertin, J Pierre Jouany, Karl Dawson. AGFD 148-The strategy of alleviating mycotoxin impact on the animal: A comprehensive study of mycotoxin adsorption through the use of Saccharomyces cerevisiae cell wall. 235. American Chemical Society National Meeting, American Chemical Society (ACS). USA., Apr 2008, Nouvelle-Orléans, United States. ⟨hal-02758338⟩

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