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Differential immune gene expression associated with contemporary range expansion of two invasive rodents in Senegal

Abstract : Biological invasions are major anthropogenic changes associated with threats to biodiversity and health. However, what determines the successful establishment and spread of introduced populations remains unclear. Here, we explore several hypotheses linking invasion success and immune phenotype traits, including those based on the evolution of increased competitive ability concept. We compared gene expression profiles between anciently and recently established populations of two major invading species, the house mouse Mus musculus domesticus and the black rat Rattus rattus, in Senegal (West Africa). Transcriptome analyses identified differential expression between anciently and recently established populations for 364 mouse genes and 83 rat genes. All immune-related genes displaying differential expression along the mouse invasion route were overexpressed at three of the four recently invaded sites studied. Complement activation pathway genes were overrepresented among these genes. By contrast, no particular immunological process was found to be overrepresented among the differentially expressed genes of black rat. Changes in transcriptome profiles were thus observed along invasion routes, but with different specific patterns between the two invasive species. These changes may be driven by increases in infection risks at sites recently invaded by the house mouse, and by stochastic events associated with colonization history for the black rat. These results constitute a first step toward the identification of immune eco-evolutionary processes potentially involved in the invasion success of these two rodent species.
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https://hal.inrae.fr/hal-02790736
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Submitted on : Wednesday, June 30, 2021 - 5:09:03 PM
Last modification on : Thursday, September 23, 2021 - 3:39:16 AM

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Nathalie Charbonnel, Maxime Galan, Caroline Tatard, Anne Loiseau, Christophe Amidi Diagne, et al.. Differential immune gene expression associated with contemporary range expansion of two invasive rodents in Senegal. Scientific Reports, Nature Publishing Group, 2020, Peer Community in Ecology, 10, pp.18257. ⟨10.1101/442160⟩. ⟨hal-02790736v2⟩

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