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The food contaminant, deoxynivalenol, modulates the Thelper/Treg balance and increases inflammatory bowel diseases

Abstract : The incidence of inflammatory bowel diseases (IBD) is increasing in both Western and developing countries. IBD are multifactorial disorders involving complex interactions between genetic, immune, and environmental factors such as exposure to food contaminants. Deoxynivalenol (DON) is the most prevalent mycotoxin that contaminates staple food and induces intestinal breakdown and inflammatory response. To delineate the role of DON oral exposure in IBD, we used a Dextran sulfate sodium (DSS) colitis model in rats fed with a DON-contaminated diet or a control diet for 4 weeks. Colitis was induced in the 4th week by increasing concentrations of DSS in the drinking water (0, 2, 3 or 5%). DON exacerbated body weight loss and accelerated the appearance of symptoms in animals treated with DSS. DON increased morphological damage, pro-inflammatory markers (myeloperoxidase, CXCL-1 and IL-1β) and immune cell responses. In lamina propria of the rat with colitis, DON increased adaptive and innate immune responses after anti-CD3/28 or LPS stimulation, respectively. In the spleen, DON increased IFNγ secretion and reduced Treg populations. Interestingly, De-epoxy-DON (DOM-1) a detoxified form of DON did not have any consequences on colitis. These results suggest that DON is a risk factor in the onset of IBD.
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https://hal.inrae.fr/hal-02891644
Déposant : Hélène Lesur <>
Soumis le : mardi 7 juillet 2020 - 09:13:14
Dernière modification le : mardi 11 août 2020 - 15:10:03

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Delphine Payros, Sandrine Ménard, Joëlle Laffitte, Manon Neves, Marie Tremblay-Franco, et al.. The food contaminant, deoxynivalenol, modulates the Thelper/Treg balance and increases inflammatory bowel diseases. Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02817-z⟩. ⟨hal-02891644⟩

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