Performance of the Parasympathetic Tone Activity (PTA) index to assess the intraoperative nociception using different premedication drugs in anaesthetised dogs - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles International Journal of Veterinary Science and Medicine Year : 2020

Performance of the Parasympathetic Tone Activity (PTA) index to assess the intraoperative nociception using different premedication drugs in anaesthetised dogs

Abstract

The dynamic variations of the Parasympathetic Tone Activity (PTA) index were evaluated to assess nociception in dogs undergoing anaesthetic protocols with different premedication drugs. Sixty-six dogs, divided into three groups of 22 dogs each, were given different premedication drugs “morphine” (0.2 mg/kg), “morphine + medetomidine (5 μg/kg)”, “morphine + acepromazine (0.03 mg/kg)”, then similarly induced and maintained under general anaesthesia. The PTA, HR (heart rate) and MAP (mean arterial pressure) were assessed at S (steady-state), Cut (cutaneous incision), PTAE (PTA Event, assessed 1 min before a significant PTA decrease), HDR (Haemodynamic reaction, assessed 5 min before an increase of ≥ 20% in HR and/or MAP). For each group, the dynamic variation of PTA (ΔPTA) was calculated and a Receiver Operating Characteristics (ROC) curve was performed to detect if any of the premedication drugs may alter the performance of PTA index to predict intraoperative haemodynamic reactions. In all groups, a haemodynamic reaction was detected after Cut, PTAE and HDR and was preceded with a significant decrease of PTA, except for “morphine + medetomidine” group which showed a significant drop of PTA only at PTAE and HDR. The ΔPTA showed a fair performance in all groups (a mean [95% CI] AUC of 0.73 [0.62–0.82], 0.70 [0.59–0.79] and 0.71 [0.59–0.80] respectively in morphine, morphine + ACP and morphine + medetomidine). Although ΔPTA was rather altered by the premedication drug, it was able to predict, to a certain extent, haemodynamic reactions in all groups.
Fichier principal
Vignette du fichier
S0034528821002198.pdf (743.34 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-02920461 , version 1 (02-08-2023)

Licence

Identifiers

Cite

Christelle Mansour, Nour El Hachem, Patrick Jamous, Georges Saade, Emmanuel Boselli, et al.. Performance of the Parasympathetic Tone Activity (PTA) index to assess the intraoperative nociception using different premedication drugs in anaesthetised dogs. International Journal of Veterinary Science and Medicine, 2020, 8 (1), pp.49-55. ⟨10.1080/23144599.2020.1783090⟩. ⟨hal-02920461⟩
44 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More