Skip to Main content Skip to Navigation
Journal articles

Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?

Abstract : Hazelnuts (Corylus avellanaL.) have an important role in human nutrition and health. However, they are a common cause of food allergy. Due to hazelnut varietal diversity, variety-dependent differences in the IgE-binding properties may be suspected, which could allow therapeutic strategies based on the use of hypoallergenic varieties to induce desensitization. In a proteogenomic approach, we aimed to evaluate the allergenic potential of a genetically diverse set of hazelnuts (n = 13 varieties). Minor differences were found at the level of genes encoding important allergens, namely Cor a 8, Cor a 9, and Cor a 14. Nevertheless, IgE-reactivity was similar for all varieties using sera from seven allergic individuals. The predominant IgE-reactive proteins were Cor a 9 (100%) and Cor a 1.04 (60%), with the former being the most frequently identified by a two-dimensional gel electrophoresis (2-DE)-based proteomic approach. Therefore, it seems that the conventional exclusion diet will hold its ground for the time being.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02926315
Contributor : Sabine Rossi <>
Submitted on : Monday, June 7, 2021 - 3:14:49 PM
Last modification on : Friday, June 18, 2021 - 4:11:50 PM

File

nutrients-12-02100.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Miguel Ribeiro, Joana Costa, Isabel Mafra, Sandra Cabo, Ana Paula Silva, et al.. Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?. Nutrients, MDPI, 2020, 12 (7), pp.2100. ⟨10.3390/nu12072100⟩. ⟨hal-02926315⟩

Share

Metrics

Record views

49

Files downloads

16