Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?

Abstract : Hazelnuts (Corylus avellanaL.) have an important role in human nutrition and health. However, they are a common cause of food allergy. Due to hazelnut varietal diversity, variety-dependent differences in the IgE-binding properties may be suspected, which could allow therapeutic strategies based on the use of hypoallergenic varieties to induce desensitization. In a proteogenomic approach, we aimed to evaluate the allergenic potential of a genetically diverse set of hazelnuts (n = 13 varieties). Minor differences were found at the level of genes encoding important allergens, namely Cor a 8, Cor a 9, and Cor a 14. Nevertheless, IgE-reactivity was similar for all varieties using sera from seven allergic individuals. The predominant IgE-reactive proteins were Cor a 9 (100%) and Cor a 1.04 (60%), with the former being the most frequently identified by a two-dimensional gel electrophoresis (2-DE)-based proteomic approach. Therefore, it seems that the conventional exclusion diet will hold its ground for the time being.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.inrae.fr/hal-02926315
Déposant : Sabine Rossi <>
Soumis le : lundi 31 août 2020 - 15:50:48
Dernière modification le : jeudi 3 septembre 2020 - 15:38:04

Lien texte intégral

Identifiants

Collections

Citation

Miguel Ribeiro, Joana Costa, Isabel Mafra, Sandra Cabo, Ana Paula Silva, et al.. Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?. Nutrients, MDPI, 2020, 12 (7), pp.2100. ⟨10.3390/nu12072100⟩. ⟨hal-02926315⟩

Partager

Métriques

Consultations de la notice

16