The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
14 · Rachel Foong 15,16 · Veit Grote 17 · Sido Haakma 18 · Mark Hanson 19,20 · Jennifer R. Harris 21,22 · Barbara Heude 4 · Rae-Chi Huang 15 · Hazel Inskip 20
Anne-Marie Nybo Andersen
(1)
,
Ahmed Elhakeem
(2, 3)
,
Rachel Foong
(4, 5)
,
Veit Grote
(5)
,
Sido Haakma
(5)
,
Mark Hanson
(6)
,
Jennifer Harris
(6, 7)
,
Barbara Heude
(1, 8)
,
Rae-Chi Huang
(4)
,
Hazel Inskip
(6, 9)
,
Marjo-Riitta Järvelin
(10, 11)
,
Berthold Koletzko
(5)
,
Deborah Lawlor
(2, 3, 12)
,
Maarten Lindeboom
(13)
,
Rosemary Mceachan
(14)
,
Tuija Mikkola
(15)
,
Johanna Nader
(14)
,
Angela Pinot de Moira
(1)
,
Costanza Pizzi
(14)
,
Lorenzo Richiardi
(14)
,
Sylvain Sebert
(10)
,
Ameli Schwalber
(16)
,
Jordi Sunyer
(14, 8, 17)
,
Morris Swertz
(5, 18)
,
Marina Vafeiadi
(19)
,
Martine Vrijheid
(14, 8, 17)
,
John Wright
(14)
,
Liesbeth Duijts
(1)
,
Lifecycle Project Group
,
Blandine de Lauzon-Guillain
(8)
,
Patricia Dargent-Molina
(8)
,
Maxime Cornet
(8)
,
Faryal Harrar
(8)
,
Sandrine Lioret
(8)
,
Sabine Plancoulaine
(8)
,
Vincent W V Jaddoe
(1)
,
Janine F Felix
(1)
,
Anne-Marie Nybo Andersen
,
Marie-Aline Charles
(20, 1, 8)
,
Leda Chatzi
(21)
,
Eva Corpeleijn
(22)
,
Nina Donner
(16)
,
· Ahmed Elhakeem
,
Johan G Eriksson
(23, 15, 24, 25)
1
Erasmus MC -
Erasmus University Medical Center [Rotterdam]
2 IISPV - Institut d'Investigació Sanitària Pere Virgili [Tarragona]
3 BIODonostia Research Institute
4 UNITO - Università degli studi di Torino = University of Turin
5 University of Southampton
6 University of Bristol [Bristol]
7 ITU - IT University of Copenhagen
8 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
9 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
10 University of Manchester [Manchester]
11 University of Groningen [Groningen]
12 UOC - University of Crete [Heraklion]
13 USC - University of Southern California
14 NIPH - Norwegian Institute of Public Health [Oslo]
15 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
16 IMIM-Hospital del Mar
17 ELFE - Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS)
18 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
19 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
20 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
21 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
22 UPF - Universitat Pompeu Fabra [Barcelona]
23 UPV / EHU - University of the Basque Country = Euskal Herriko Unibertsitatea
24 UV - Universitat de València
25 Conselleria de Sanitat
2 IISPV - Institut d'Investigació Sanitària Pere Virgili [Tarragona]
3 BIODonostia Research Institute
4 UNITO - Università degli studi di Torino = University of Turin
5 University of Southampton
6 University of Bristol [Bristol]
7 ITU - IT University of Copenhagen
8 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
9 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
10 University of Manchester [Manchester]
11 University of Groningen [Groningen]
12 UOC - University of Crete [Heraklion]
13 USC - University of Southern California
14 NIPH - Norwegian Institute of Public Health [Oslo]
15 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
16 IMIM-Hospital del Mar
17 ELFE - Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS)
18 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
19 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
20 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
21 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
22 UPF - Universitat Pompeu Fabra [Barcelona]
23 UPV / EHU - University of the Basque Country = Euskal Herriko Unibertsitatea
24 UV - Universitat de València
25 Conselleria de Sanitat
Ahmed Elhakeem
- Fonction : Auteur
- PersonId : 802509
- ORCID : 0000-0001-7637-6360
Veit Grote
- Fonction : Auteur
- PersonId : 795612
- ORCID : 0000-0001-7168-2385
Barbara Heude
- Fonction : Auteur
- PersonId : 739512
- IdHAL : barbaraheude
- ORCID : 0000-0002-1565-1629
- IdRef : 083324593
Rae-Chi Huang
- Fonction : Auteur
- PersonId : 795613
- ORCID : 0000-0002-8464-6639
Deborah Lawlor
- Fonction : Auteur
- PersonId : 801130
- ORCID : 0000-0002-6793-2262
- IdRef : 133052893
Martine Vrijheid
- Fonction : Auteur
- PersonId : 763761
- ORCID : 0000-0002-7090-1758
- IdRef : 225451581
Lifecycle Project Group
- Fonction : Auteur
Blandine de Lauzon-Guillain
- Fonction : Collaborateur
- PersonId : 174012
- IdHAL : blandine-de-lauzon-guillain
- ORCID : 0000-0001-5887-8842
- IdRef : 110840593
Patricia Dargent-Molina
- Fonction : Collaborateur
- PersonId : 867568
Maxime Cornet
- Fonction : Collaborateur
- PersonId : 1149426
- IdHAL : maxime-cornet
- ORCID : 0000-0002-2332-8266
Sabine Plancoulaine
- Fonction : Collaborateur
- PersonId : 174162
- IdHAL : sabine-plancoulaine
- ORCID : 0000-0003-0725-8306
- IdRef : 226566560
Anne-Marie Nybo Andersen
- Fonction : Auteur
Marie-Aline Charles
- Fonction : Auteur
- PersonId : 756717
- ORCID : 0000-0003-4025-4390
- IdRef : 095063277
· Ahmed Elhakeem
- Fonction : Auteur
Résumé
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.