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Evolution of sex hormone binding globulins reveals early gene duplication at the root of vertebrates

Abstract : Sex hormone-binding globulin (Shbg) is an important vertebrate blood carrier protein synthetized in the liver and involved in the transport and local regulation of sex steroids in target tissues. A novel shbg gene (shbgb) with a predominant ovarian expression was recently characterized. Being initially found only in salmonids, this shbgb was originally thought to result from the Salmonid-specific whole genome duplication. Using updated transcriptomic and genomic resources we identified Shbgb orthologs in non-salmonid teleosts (European eel, arowana), holosteans (spotted gar, bowfin), polypteriformes (reedfish), agnatha (sea lamprey) and in amphibians, and found that the classical Shbg gene (Shbga) displays a predominant hepatic expression whereas Shbgb has a predominant gonadal expression. Together, these results indicate that these two Shgb genes most likely originate from a whole genome duplication event at the root of vertebrate evolution, followed by numerous and independent losses and by tissue expression specialization of Shbga and Shbgb paralogs.
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https://hal.inrae.fr/hal-02987822
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Submitted on : Wednesday, November 4, 2020 - 11:23:45 AM
Last modification on : Thursday, August 5, 2021 - 3:55:03 AM

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Yann Guiguen, Jérémy Pasquier, Alexis Fostier, Julien Bobe. Evolution of sex hormone binding globulins reveals early gene duplication at the root of vertebrates. General and Comparative Endocrinology, Elsevier, 2021, 300, pp.1-8. ⟨10.1016/j.ygcen.2020.113646⟩. ⟨hal-02987822⟩

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