Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

An integrative atlas of chicken long non-coding genes and their annotations across 25 tissues

Abstract : Long non-coding RNAs (LNC) regulate numerous biological processes. In contrast to human, the identification of LNC in farm species, like chicken, is still lacunar. We propose a catalogue of 52,075 chicken genes enriched in LNC (http://www.frage ncode .org/), built from the Ensembl reference extended using novel LNC modelled here from 364 RNA-seq and LNC from four public databases. The Ensembl reference grew from 4,643 to 30,084 LNC, of which 59% and 41% with expression ≥ 0.5 and ≥ 1 TPM respectively. Characterization of these LNC relatively to the closest protein coding genes (PCG) revealed that 79% of LNC are in intergenic regions, as in other species. Expression analysis across 25 tissues revealed an enrichment of co-expressed LNC:PCG pairs, suggesting co-regulation and/or co-function. As expected LNC were more tissue-specific than PCG (25% vs. 10%). Similarly to human, 16% of chicken LNC hosted one or more miRNA. We highlighted a new chicken LNC, hosting miR155, conserved in human, highly expressed in immune tissues like miR155, and correlated with immunity-related PCG in both species. Among LNC:PCG pairs tissue-specific in the same tissue, we revealed an enrichment of divergent pairs with the PCG coding transcription factors, as for example LHX5, HXD3 and TBX4, in both human and chicken.
Liste complète des métadonnées
Déposant : Hervé Acloque <>
Soumis le : vendredi 4 décembre 2020 - 09:48:14
Dernière modification le : vendredi 26 février 2021 - 10:58:03


Distributed under a Creative Commons Paternité 4.0 International License



Frédéric Jehl, Kévin Muret, Maria Bernard, Morgane Boutin, Laetitia Lagoutte, et al.. An integrative atlas of chicken long non-coding genes and their annotations across 25 tissues. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.1-17. ⟨10.1038/s41598-020-77586-x⟩. ⟨hal-03039897⟩



Consultations de la notice


Téléchargements de fichiers