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Evolution of sex hormone binding globulins reveals early gene duplication at the root of vertebrates

Abstract : Sex hormone-binding globulin (Shbg) is an important vertebrate blood carrier protein synthetized in the liver and involved in the transport and local regulation of sex steroids in target tissues. A novel shbg gene (shbgb) with a predominant ovarian expression was recently characterized. Being initially found only in salmonids, this shbgb was originally thought to result from the Salmonid-specific whole genome duplication. Using updated transcriptomic and genomic resources we identified Shbgb orthologs in non-salmonid teleosts (European eel, arowana), holosteans (spotted gar, bowfin), polypteriformes (reedfish), agnatha (sea lamprey) and in amphibians, and found that the classical Shbg gene ( Shbga ) displays a predominant hepatic expression whereas Shbgb has a predominant gonadal expression. Together, these results indicate that these two Shgb genes most likely originate from a whole genome duplication event at the root of vertebrate evolution, followed by numerous and independent losses and by tissue expression specialization of Shbga and Shbgb paralogs.
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https://hal.inrae.fr/hal-03048977
Contributor : Maryse Corvaisier Connect in order to contact the contributor
Submitted on : Wednesday, December 9, 2020 - 4:09:08 PM
Last modification on : Thursday, August 5, 2021 - 3:55:06 AM

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Yann Guiguen, Jérémy Pasquier, Alexis Fostier, Julien Bobe. Evolution of sex hormone binding globulins reveals early gene duplication at the root of vertebrates. 2020. ⟨hal-03048977⟩

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