Here we compared the reproductive performance of the French rabbit breed Fauve-de-Bourgogne (Fauve), the maternal rabbit line INRA-1777 (INRA), and their cross (Crossed). We followed the life of female rabbits of the three genotypes from 70 days of life until the weaning of litters produced from the third artificial insemination (AI) attempt. They had the same age, were house in the same room, were manage under a reproductive rhythm of 42 days and received antibiotic free diets. Crossed females were heavier at first AI than Fauve females (4.2 vs 3.9 kg; P<0.05), INRA females being between both genotypes (4.1 kg). Between the first AI attempt and the birth of the first litters, we observed the presence of Pasteurella spp. This pathogen impaired the prolificacy of all genotypes and caused mortality of females around parturitions from the second AI attempts. Most losses were from the INRA genotype (four diagnosed deaths for INRA, one for Crossed and none for Fauve females). In brief, the overall losses of Fauve, INRA and Crossed females were two, fourteen and four females, respectively. The high female survival (91%), together with an acceptable reproductive performance (7.5 newborn kits, kit survival during lactation of 80% and weaning weight of kits of 871 g) of Crossed females, indicates that this maternal cross combine the alleged rusticity of the Fauve-de-Bourgogne breed with the reproductive potential of INRA maternal line.