Flowering plants are the foundation of human civilization, providing biomass for food, fuel, and materials to satisfy human needs, dependent on fertile soil, adequate water, and favorable weather. Conversely, failure of any of these inputs has caused catastrophes. Today, human appropriation of biomass is threatening planetary boundaries, inducing social and political unrest worldwide. Human societies are bound to rethink agriculture and forestry to restore and safeguard natural resources while improving the overall quality of life. Here, we explore why and how. Through an evolutionary and quantitative analysis of agriculture, and bridging plant and Earth sciences, we anticipate the advent of a research and policy framework, integrating plant science in all sectors: the economy, local and global governance, and geopolitics.