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Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High‐Fat Diet‐Fed Mice

Abstract : Scope Current evidence supports the beneficial effect of polyphenols on the management of obesity and associated comorbidities. This is the case for propolis, a polyphenol-rich substance produced by bees. The aim of the present study is to evaluate the effect of a poplar propolis ethanolic extract (PPEE) on obesity and glucose homeostasis, and to unveil its putative molecular mechanisms of action. Methods and results Male high-fat (HF) diet-fed mice are administered PPEE for 12 weeks. PPEE supplementation reduces the HF-mediated adiposity index, adipocyte hypertrophy, and body weight gain. It also improves HOMA-IR and fasting glucose levels. Gene expression profiling of adipose tissue (AT) shows an induction of mRNA related to lipid catabolism and mitochondrial biogenesis and inhibition of mRNA coding for inflammatory markers. Interestingly, several Nrf2-target genes are induced in AT following administration of PPEE. The ability of PPEE to induce the expression of Nrf2-target genes is studied in adipocytes. PPEE is found to transactivate the Nrf2 response element and the Nrf2 DNA-binding, suggesting that part of the effect of PPEE can be mediated by Nrf2. Conclusion PPEE supplementation may represent an interesting preventive strategy to tackle the onset of obesity and associated metabolic disorders.
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https://hal.inrae.fr/hal-03157023
Contributor : Nelly Lucas <>
Submitted on : Friday, May 14, 2021 - 2:30:13 PM
Last modification on : Friday, May 28, 2021 - 4:42:31 PM
Long-term archiving on: : Sunday, August 15, 2021 - 6:21:05 PM

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Nicolas Cardinault, Franck Tourniaire, Julien Astier, Charlène Couturier, Estelle Perrin, et al.. Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High‐Fat Diet‐Fed Mice. Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2020, 64 (18), pp.2000275. ⟨10.1002/mnfr.202000275⟩. ⟨hal-03157023⟩

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