Skip to Main content Skip to Navigation
Journal articles

Vagally mediated gut-brain relationships in appetite control-insights from porcine studies

Abstract : Signals arising from the upper part of the gut are essential for the regulation of food intake, particularly satiation. This information is supplied to the brain partly by vagal nervous afferents. The porcine model, because of its sizeable gyrencephalic brain, omnivorous regimen, and comparative anatomy of the proximal part of the gut to that of humans, has provided several important insights relating to the relevance of vagally mediated gut-brain relationships to the regulation of food intake. Furthermore, its large size combined with the capacity to become obese while overeating a western diet makes it a pivotal addition to existing murine models, especially for translational studies relating to obesity. How gastric, proximal intestinal, and portal information relating to meal arrival and transit are encoded by vagal afferents and their further processing by primary and secondary brain projections are reviewed. Their peripheral and central plasticities in the context of obesity are emphasized. We also present recent insights derived from chronic stimulation of the abdominal vagi with specific reference to the modulation of mesolimbic structures and their role in the restoration of insulin sensitivity in the obese miniature pig model.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03173254
Contributor : Emilie Bernard <>
Submitted on : Thursday, March 18, 2021 - 12:49:28 PM
Last modification on : Tuesday, September 7, 2021 - 3:44:36 PM

File

Malbert_2021.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Charles-Henri Malbert. Vagally mediated gut-brain relationships in appetite control-insights from porcine studies. Nutrients, MDPI, 2021, 13 (2), ⟨10.3390/nu13020467⟩. ⟨hal-03173254⟩

Share

Metrics

Record views

12

Files downloads

13