Skip to Main content Skip to Navigation
Journal articles

Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis

Abstract : The development and progression of atherosclerosis (ATH) involves lipid accumulation, oxidative stress and both vascular and blood cell dysfunction. Erythrocytes, the main circulating cells in the body, exert determinant roles in the gas transport between tissues. Erythrocytes have long been considered as simple bystanders in cardiovascular diseases, including ATH. This review highlights recent knowledge concerning the role of erythrocytes being more than just passive gas carriers, as potent contributors to atherosclerotic plaque progression. Erythrocyte physiology and ATH pathology is first described. Then, a specific chapter delineates the numerous links between erythrocytes and atherogenesis. In particular, we discuss the impact of extravasated erythrocytes in plaque iron homeostasis with potential pathological consequences. Hyperglycaemia is recognised as a significant aggravating contributor to the development of ATH. Then, a special focus is made on glycoxidative modifications of erythrocytes and their role in ATH. This chapter includes recent data proposing glycoxidised erythrocytes as putative contributors to enhanced atherothrombosis in diabetic patients.
Complete list of metadata

https://hal.inrae.fr/hal-03256950
Contributor : Nathalie Seguin <>
Submitted on : Thursday, June 10, 2021 - 3:32:54 PM
Last modification on : Wednesday, August 25, 2021 - 1:54:01 PM

File

Turpin-MDPI-2021.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Chloé Turpin, Aurélie Catan, Olivier Meilhac, Emmanuel Bourdon, François Canonne-Hergaux, et al.. Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis. International Journal of Molecular Sciences, MDPI, 2021, 22 (11), 30 p. ⟨10.3390/ijms22115843⟩. ⟨hal-03256950⟩

Share

Metrics

Record views

68

Files downloads

69