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Distinct Pathways Carry Out α and β Galactosylation of Secondary Cell Wall Polysaccharide in Bacillus anthracis

Abstract : Peptidoglycan is a conserved extracellular macromolecule that protects bacterial cells from turgor pressure. Peptidoglycan of Gram-positive bacteria serves as a scaffold for the attachment of polymers that provide defined bacterial interactions with their environment. One such polymer, B. anthracis SCWP, is pyruvylated at its distal end to serve as a receptor for secreted proteins bearing the S-layer homology domain. Repeat units of SCWP carry three galactoses in B. anthracis . Glycosylation is a recurring theme in nature and often represents a means to mask or alter conserved molecular signatures from intruders such as bacteriophages. Several glycosyltransferase families have been described based on bioinformatics prediction, but few have been studied. Here, we describe the glycosyltransferases that mediate the galactosylation of B. anthracis SCWP.
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https://hal.inrae.fr/hal-03298691
Contributor : Line Touloumet <>
Submitted on : Friday, July 23, 2021 - 5:41:39 PM
Last modification on : Saturday, July 24, 2021 - 3:50:42 AM

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Alice Chateau, So Young Oh, Anastasia Tomatsidou, Inka Brockhausen, Olaf Schneewind, et al.. Distinct Pathways Carry Out α and β Galactosylation of Secondary Cell Wall Polysaccharide in Bacillus anthracis. Journal of Bacteriology, American Society for Microbiology, 2020, 202 (15), ⟨10.1128/JB.00191-20⟩. ⟨hal-03298691⟩

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