An integrative genomics approach for deciphering the complex interactions between ascorbate metabolism and fruit growth and composition in tomato - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles (Review Article) Comptes Rendus. Biologies Year : 2009

An integrative genomics approach for deciphering the complex interactions between ascorbate metabolism and fruit growth and composition in tomato

Virginie Garcia
Laurent Gil
  • Function : Author
Louise Gilbert
  • Function : Author
Johann Petit
  • Function : Author
Annick Moing
Martine Lemaire-Chamley
Pierre Baldet
Christophe Rothan
Connectez-vous pour contacter l'auteur

Abstract

Very few reports have studied the interactions between ascorbate and fruit metabolism. In order to get insights into the complex relationships between ascorbate biosynthesis/recycling and other metabolic pathways in the fruit, we undertook a fruit systems biology approach. To this end, we have produced tomato transgenic lines altered in ascorbate content and redox ratio by RNAitargeting several key enzymes involved in ascorbate biosynthesis (2 enzymes) and recycling (2 enzymes). In the VTC (ViTamin C) Fruit project, we then generated phenotypic and genomic (transcriptome, proteome, metabolome) data from wild type and mutant tomato fruit at two stages of fruit development, and developed or implemented statistical and bioinformatic tools as a web application (named VTC Tool box) necessary to store, analyse and integrate experimental data in tomato. By using Kohonen's self-organizing maps (SOMs) to cluster the biological data, pair-wise Pearson correlation analyses and simultaneous visualization

Dates and versions

hal-03371236 , version 1 (08-10-2021)

Identifiers

Cite

Virginie Garcia, Rebecca Stevens, Laurent Gil, Louise Gilbert, Noé Gest, et al.. An integrative genomics approach for deciphering the complex interactions between ascorbate metabolism and fruit growth and composition in tomato. Comptes Rendus. Biologies, 2009, 332, pp.1007 - 1021. ⟨10.1016/j.crvi.2009.09.013⟩. ⟨hal-03371236⟩
15 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More