Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1) - Archive ouverte HAL Access content directly
Journal Articles Molecular and Cellular Endocrinology Year : 2021

Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)

(1) , (1) , (1) , (2) , (2) , (2) , (1, 3) , (1) , (1)
1
2
3

Abstract

In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including the hypothalamic GnRH neuronal network, the pituitary gonadotropin secretion and the ovarian follicle growth and steroidogenesis. Several hormones and neuropeptides or metabolites are important signals between energy balance and reproduction. These energy sensors mediate their action on reproductive cells through specific kinases or signaling pathways. This review focuses on the role of three main enzymes-specifically, mTOR, AMPK, and SIRT1 at the hypothalamic pituitary and ovarian axis in normal female fertility and then we discuss their possible involvement in some women reproductive disorders known to be associated with metabolic complications, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF).
Fichier principal
Vignette du fichier
S0303720720304159.pdf (401.55 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03468082 , version 1 (15-12-2022)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Anthony Estienne, Alice Bongrani, Christelle Ramé, Patrycja Kurowska, Klaudia Błaszczyk, et al.. Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1). Molecular and Cellular Endocrinology, 2021, 521, pp.1-12. ⟨10.1016/j.mce.2020.111113⟩. ⟨hal-03468082⟩
40 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More