Global analysis of human SARS-CoV-2 infection and host-virus interaction - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Preprints, Working Papers, ... Year : 2020

Global analysis of human SARS-CoV-2 infection and host-virus interaction

Vanessa Aguiar-Pulido
Eric Dawson
  • Function : Author
Andrea Guarracino
  • Function : Author
Andreas Gruber
  • Function : Author
Lukas Heumos
  • Function : Author
Alexander Kanitz
Avantika Lal
  • Function : Author
Brett Pickett
  • Function : Author
Carlos Ruiz-Arenas
Olaitan Awe
  • Function : Author
Suhana Bedi
  • Function : Author
Ben Busby
  • Function : Author
Marielena Georgaki
  • Function : Author
Chela James
  • Function : Author
Itziar Martinez Gonzalez
  • Function : Author
Birgit Meldal
  • Function : Author
Scheila Mucha
  • Function : Author
Noushin Nabavi
  • Function : Author
Jakke Neiro
  • Function : Author
Núria Queralt-Rosinach
  • Function : Author
Philippe Rocca-Serra
Daniel Siqueira de Oliveira
  • Function : Author
Maria Tsagiopoulou
  • Function : Author

Abstract

As part of the virtual BioHackathon 2020, we formed a working group that focused on the analysis of gene expression in the context of COVID-19. More specifically, we performed transcriptome analyses on published datasets in order to better understand the interaction between the human host and the SARS-CoV-2 virus.The ideas proposed during this hackathon were divided into five projects. Projects 1 and 2 aimed to identify human genes that are important in the process of viral infection of human cells. Projects 3 and 4 aimed to take the candidate genes identified in projects 1 and 2, as well as by independent studies, and relate them to clinical information and to possible therapeutic interventions. Finally, Project 5 aimed to package and containerize software and workflows used and generated here in a reusable manner, ultimately providing scalable and reproducible workflows.

Domains

Virology

Dates and versions

hal-03514119 , version 1 (06-01-2022)

Identifiers

Cite

Mariana Ferrarini, Vanessa Aguiar-Pulido, Eric Dawson, Andrea Guarracino, Andreas Gruber, et al.. Global analysis of human SARS-CoV-2 infection and host-virus interaction. 2022. ⟨hal-03514119⟩
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