During the last decades, the demand for poultry meat, especially further-processed products, has dramatically increased. Consequently, the poultry industry has been pushed to increase breast yield and to produce heavier birds for further processing. However, industry also has to deal with new meat quality issues that seriously affect the taste and nutritional qualities but also the processing ability. As in pork, the technological and sensory defects are often related to variations in energy metabolism, which influence the postmortem pH drop. This variability mainly concerns the breast muscle, whose metabolism is fully glycolytic, and affects color, water holding capacity and texture of the cooked meat. Over the past decade, several myodegenerative anomalies, described as myopathies, have appeared first in countries that use high-yielding strains with high slaughter weights. The main are "white striping", "wooden breast" and "spaghetti meat" that mainly affect the breast muscle of broilers. The consequences of these anomalies on quality are dramatic because they greatly affect the visual aspect (until rejection by the consumer) but also the processing yields. The poultry industry is looking for solutions related to genetics, nutrition or management practices. The research conducted to date has improved our knowledge of the biological processes involved in the occurrence of meat defects, but for now, no solution has been identified to reduce significantly their incidence without affecting growing performance. We can nevertheless make the assumption that part of the solution will go through genetic improvement, but also (and certainly in addition) nutritional or management solutions. In practical terms, the implementation of these solutions will be facilitated by the development of molecular tools that could allow a deeper phenotyping of meat defects, ideally on alive birds. This review aims to present recent advances on the search for biological or genetic markers issued from various high throughput methodologies, and whose integration could lead to new diagnostic tools for a better screening of broilers affected by meat defects.