An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Genome Biology Year : 2016

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Dianjianyi Sun
  • Function : Author
Shengxu Li
  • Function : Author
Wei Chen


Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to address puzzling findings surrounding mortality rates and incidence of cardio-metabolic disease such as: (1) women consistently exhibiting lower mortality than men despite having higher levels of morbidity; (2) racial/ethnic groups having different mortality rates even after adjusting for socioeconomic differences; (3) the black/white mortality cross-over effect in late adulthood; and (4) Hispanics in the United States having a longer life expectancy than Caucasians despite having a higher burden of traditional cardio-metabolic risk factors. Results We analyzed blood, saliva, and brain samples from seven different racial/ethnic groups. We assessed the intrinsic epigenetic age acceleration of blood (independent of blood cell counts) and the extrinsic epigenetic aging rates of blood (dependent on blood cell counts and tracks the age of the immune system). In blood, Hispanics and Tsimane Amerindians have lower intrinsic but higher extrinsic epigenetic aging rates than Caucasians. African-Americans have lower extrinsic epigenetic aging rates than Caucasians and Hispanics but no differences were found for the intrinsic measure. Men have higher epigenetic aging rates than women in blood, saliva, and brain tissue. Conclusions Epigenetic aging rates are significantly associated with sex, race/ethnicity, and to a lesser extent with CHD risk factors, but not with incident CHD outcomes. These results may help elucidate lower than expected mortality rates observed in Hispanics, older African-Americans, and women.
Fichier principal
Vignette du fichier
s13059-016-1030-0.pdf (2.58 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03642312 , version 1 (15-04-2022)




Steve Horvath, Michael Gurven, Morgan Levine, Benjamin Trumble, Hillard Kaplan, et al.. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biology, 2016, 17 (1), pp.171. ⟨10.1186/s13059-016-1030-0⟩. ⟨hal-03642312⟩
43 View
39 Download



Gmail Mastodon Facebook X LinkedIn More