Characterization of the Skeletal Muscle Proteome in Undernourished Old Rats - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2022

Characterization of the Skeletal Muscle Proteome in Undernourished Old Rats

Jérôme Salles
Christophe Giraudet
  • Function : Author
  • PersonId : 1206082
Phelipe Sanchez
  • Function : Author
  • PersonId : 1207870
Véronique Patrac
  • Function : Author
  • PersonId : 1207723
Yves Boirie
Stéphane Walrand
Marine Gueugneau


Aging is associated with a progressive loss of skeletal muscle mass and function termed sarcopenia. Various metabolic alterations that occur with aging also increase the risk of undernutrition, which can worsen age-related sarcopenia. However, the impact of undernutrition on aged skeletal muscle remains largely under-researched. To build a deeper understanding of the cellular and molecular mechanisms underlying age-related sarcopenia, we characterized the undernutritioninduced changes in the skeletal muscle proteome in old rats. For this study, 20-month-old male rats were fed 50% or 100% of their spontaneous intake for 12 weeks, and proteomic analysis was performed on both slow- and fast-twitch muscles. Proteomic profiling of undernourished aged skeletal muscle revealed that undernutrition has profound effects on muscle proteome independently of its effect on muscle mass. Undernutrition-induced changes in muscle proteome appear to be muscle-type-specific: slow-twitch muscle showed a broad pattern of differential expression in proteins important for energy metabolism, whereas fast-twitch muscle mainly showed changes in protein turnover between undernourished and control rats. This first proteomic analysis of undernourished aged skeletal muscle provides new molecular-level insight to explain phenotypic changes in undernourished aged muscle. We anticipate this work as a starting point to define new biomarkers associated with undernutrition-induced muscle loss in the elderly
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hal-03685826 , version 1 (02-06-2022)




Caroline Barbé, Jérôme Salles, Christophe C. Chambon, Christophe Giraudet, Phelipe Sanchez, et al.. Characterization of the Skeletal Muscle Proteome in Undernourished Old Rats. International Journal of Molecular Sciences, 2022, 23 (9), ⟨10.3390/ijms23094762⟩. ⟨hal-03685826⟩
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