Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy - Archive ouverte HAL Access content directly
Journal Articles Cells Year : 2022

Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

(1) , (1) , (1) , (2) , (1) , (2) , (1)
1
2
Simon Schnebert
Maxime Goguet
  • Function : relator_co_first_author
  • PersonId : 1153140
  • IdHAL : maxime-goguet
Emilio J Vélez
Florian Beaumatin

Abstract

Autophagy is a pleiotropic and evolutionarily conserved process in eukaryotes that encompasses different types of mechanisms by which cells deliver cytoplasmic constituents to the lysosome for degradation. Interestingly, in mammals, two different and specialized autophagic pathways, (i) the chaperone-mediated autophagy (CMA) and (ii) the endosomal microautophagy (eMI), both rely on the use of the same cytosolic chaperone HSPA8 (also known as HSC70) for targeting specific substrates to the lysosome. However, this is not true for all organisms, and differences exist between species with respect to the coexistence of these two autophagic routes. In this paper, we present an in-depth analysis of the evolutionary history of the main components of CMA and eMI and discuss how the observed discrepancies between species may contribute to improving our knowledge of these two functions and their interplays.
Fichier principal
Vignette du fichier
Schnebert_cells-2022.pdf (1.64 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY - Attribution

Dates and versions

hal-03746575 , version 1 (05-08-2022)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Simon Schnebert, Maxime Goguet, Emilio J Vélez, Alexandra Depincé, Florian Beaumatin, et al.. Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy. Cells, 2022, 11 (12), pp.1945. ⟨10.3390/cells11121945⟩. ⟨hal-03746575⟩
12 View
8 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More