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Journal Articles (Review Article) Nutrients Year : 2022

Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies

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Abstract

Observational studies classically find an inverse relationship between human plasma 25-hydroxyvitamin D concentration and obesity. However, interventional and genetic studies have failed to provide clear conclusions on the causal effect of vitamin D on obesity/adiposity. Likewise, vitamin D supplementation in obese rodents has mostly failed to improve obesity parameters, whereas several lines of evidence in rodents and prospective studies in humans point to a preventive effect of vitamin D supplementation on the onset of obesity. Recent studies investigating the impact of maternal vitamin D deficiency in women and in rodent models on adipose tissue biology programming in offspring further support a preventive metabolically driven effect of vitamin D sufficiency. The aim of this review is to summarize the state of the knowledge on the relationship between vitamin D and obesity/adiposity in humans and in rodents and the impact of maternal vitamin D deficiency on the metabolic trajectory of the offspring.
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hal-03777049 , version 1 (14-09-2022)

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Attribution - CC BY 4.0

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Imene Bennour, Nicole Haroun, Flavie Sicard, Lourdes Mounien, Jean-François Landrier. Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies. Nutrients, 2022, 14 (10), pp.1-16. ⟨10.3390/nu14102049⟩. ⟨hal-03777049⟩
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