Browning Epicardial Adipose Tissue: Friend or Foe? - Archive ouverte HAL Access content directly
Journal Articles (Review Article) Cells Year : 2022

Browning Epicardial Adipose Tissue: Friend or Foe?

(1) , (1, 2) , (3) , (1) , (1) , (1, 2) , (1, 4)
1
2
3
4

Abstract

The epicardial adipose tissue (EAT) is the visceral fat depot of the heart which is highly plastic and in direct contact with myocardium and coronary arteries. Because of its singular proximity with the myocardium, the adipokines and pro-inflammatory molecules secreted by this tissue may directly affect the metabolism of the heart and coronary arteries. Its accumulation, measured by recent new non-invasive imaging modalities, has been prospectively associated with the onset and progression of coronary artery disease (CAD) and atrial fibrillation in humans. Recent studies have shown that EAT exhibits beige fat-like features, and express uncoupling protein 1 (UCP-1) at both mRNA and protein levels. However, this thermogenic potential could be lost with age, obesity and CAD. Here we provide an overview of the physiological and pathophysiological relevance of EAT and further discuss whether its thermogenic properties may serve as a target for obesity therapeutic management with a specific focus on the role of immune cells in this beiging phenomenon.
Fichier principal
Vignette du fichier
doukbi_cells-2022.pdf (1.31 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03782532 , version 1 (21-09-2022)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Elisa Doukbi, Astrid Soghomonian, Coralie Sengenès, Shaista Ahmed, Patricia Ancel, et al.. Browning Epicardial Adipose Tissue: Friend or Foe?. Cells, 2022, 11 (6), pp. 991. ⟨10.3390/cells11060991⟩. ⟨hal-03782532⟩
12 View
2 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More