Skip to Main content Skip to Navigation
New interface
Journal articles

Phages, anti-CRISPR proteins, and drug-resistant bacteria: what do we know about this triad?

Abstract : Phages are viruses that infect bacteria, relying on their genetic machinery to replicate. To survive the constant attack of phages, bacteria have developed diverse defense strategies to act against them. Nevertheless, phages rapidly co-evolve to overcome these barriers, resulting in a constant, and often surprising, molecular arms race. Thus, some phages have evolved protein inhibitors known as anti-CRISPRs (∼50–150 amino acids), which antagonize the bacterial CRISPR-Cas immune response. To date, around 45 anti-CRISPRs proteins with different mechanisms and structures have been discovered against the CRISPR-Cas type I and type II present in important animal and human pathogens such as Escherichia, Morganella, Klebsiella, Enterococcus, Pseudomonas, Staphylococcus, and Salmonella. Considering the alarming growth of antibiotic resistance, phage therapy, either alone or in combination with antibiotics, appears to be a promising alternative for the treatment of many bacterial infections. In this review, we illustrated the biological and clinical aspects of using phage therapy; furthermore, the CRISPR-Cas mechanism, and the interesting activity of anti-CRISPR proteins as a possible weapon to combat bacteria.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03823659
Contributor : Stéphanie DUTILLOY Connect in order to contact the contributor
Submitted on : Friday, October 21, 2022 - 9:53:11 AM
Last modification on : Saturday, October 22, 2022 - 5:44:50 AM

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Collections

Citation

Andrés Ceballos-Garzon, Angela Muñoz, Juan Plata, Zilpa Sanchez-Quitian, Jose Ramos-Vivas. Phages, anti-CRISPR proteins, and drug-resistant bacteria: what do we know about this triad?. Pathogens and Disease, 2022, ⟨10.1093/femspd/ftac039⟩. ⟨hal-03823659⟩

Share

Metrics

Record views

0