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Journal Articles Critical Reviews in Oncology/Hematology Year : 2022

A bone paradigm challenging the standard model of myeloma oncogenesis

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Jean-Pascal Capp

Abstract

The standard model of multiple myeloma (MM) oncogenesis from monoclonal gammopathy of undetermined significance (MGUS) relies on genetic instability in the normal counterparts of MM cells. However, the impor-tance of both MGUS-associated and MM-induced bone changes has been recently re-appraised, emphasizing the bone microenvironment (BME) as a tissue of significance. In this review, we propose that early BME alterations (bone senescence and inflammation, i.e., bone inflamm'aging) at the pre-MGUS stage could be causal, and not simply permissive, and creative of phenotypic instability and genetic alterations thanks to the concept of tissue disruption-induced cell stochasticity (TiDiS). This article offers a bone scenario challenging the chromosome-and-gene-centric standard model of MM oncogenesis. The high incidence of both MGUS and MM in Gaucher disease supports such a scenario.
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Dates and versions

hal-03829644 , version 1 (25-10-2022)

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Jean-Pascal Capp, Régis Bataille. A bone paradigm challenging the standard model of myeloma oncogenesis. Critical Reviews in Oncology/Hematology, 2022, 172, ⟨10.1016/j.critrevonc.2022.103640⟩. ⟨hal-03829644⟩
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