Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
Résumé
The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly knownas the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueousethanolicextract of the roots. Among the seven isolated saponins, two have never been reportedbefore: 3-O--L-rhamnopyranosyl-(1!2)--D-glucopyranosyl-(1!2)-- D- glucuronopyranosyl-22-Oacetylolean-12-ene-3,16,22,30-tetrol, and 3-O--D- xylopyranosyl-(1!2)--D-glucuronopyranosylwistariasapogenolA. Based on the close structures between the saponins from W. sinensis, and theglycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by theseglycosides was evaluated.
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