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Mechanisms of muscle atrophy: from UPS implication in rodent models to human biomarkers

Abstract : The ubiquitin proteasome system (UPS) is a major player of skeletal muscle wasting, a common characteristic of many diseases (cancer, sepsis, heart failure, kidney diseases, etc.) that negatively impacts treatment and life prognosis. In the early 2000, the notion of "atrogenes" (atrophy-related genes) was proposed for genes that were systematically up regulated during catabolic situations in rodents, which included 2 founding members, the E3 ubiquitin ligases MAFbx/Atrogin-1 and MuRF1/TRIM63 [1]. Interestingly, MuRF1 is so far the only E3 ligase known for targeting several sarcomeric proteins (a-actin, MYHC, Troponin I, telethonin) and we recently identified the E2 ubiquitin conjugating enzymes that bring the catalytic activity for MuRF1-dependent protein degradation [2, 3]. Besides rodent models, we and others demonstrated that MAFbx and MuRF1 are also gold standard atrogenes in human pathologies and we recently found that numerous proteins may be part of a muscle atrophy program in chronic kidney disease and lung cancer patients [4]. In addition, we have identified blood markers that reflect skeletal muscle loss in patients suffering from several pathologies.
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https://hal.inrae.fr/hal-03858980
Contributor : Daniel Taillandier Connect in order to contact the contributor
Submitted on : Friday, November 18, 2022 - 8:26:33 AM
Last modification on : Saturday, November 19, 2022 - 3:26:34 AM

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Daniel Taillandier, Dulce Peris-Moreno, Cécile Polge. Mechanisms of muscle atrophy: from UPS implication in rodent models to human biomarkers. 2022 Padua Days on Muscle & Mobility Medicine, University of Padova, Mar 2022, Padova, Italy. ⟨hal-03858980⟩

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