Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Cell Reports Year : 2021

Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease

Dorines Rosario
  • Function : Author
Gholamreza Bidkhori
  • Function : Author
Sunjae Lee
  • Function : Author
Janis Bedarf
  • Function : Author
Falk Hildebrand
  • Function : Author
Mathias Uhlen
  • Function : Author
Stanislav Dusko Ehrlich
  • Function : Author
Gordon Proctor
  • Function : Author
Ullrich Wüllner
  • Function : Author
Adil Mardinoglu
  • Function : Author
Saeed Shoaie
  • Function : Author

Abstract

Parkinson's disease (PD) is the most common progressive neurological disorder compromising motor functions. However, nonmotor symptoms, such as gastrointestinal (GI) dysfunction, precede those affecting movement. Evidence of an early involvement of the GI tract and enteric nervous system highlights the need for better understanding of the role of gut microbiota in GI complications in PD. Here, we investigate the gut microbiome of patients with PD using metagenomics and serum metabolomics. We integrate these data using metabolic modeling and construct an integrative correlation network giving insight into key microbial species linked with disease severity, GI dysfunction, and age of patients with PD. Functional analysis reveals an increased microbial capability to degrade mucin and host glycans in PD. Personalized community-level metabolic modeling reveals the microbial contribution to folate deficiency and hyperhomo-cysteinemia observed in patients with PD. The metabolic modeling approach could be applied to uncover gut microbial metabolic contributions to PD pathophysiology.
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hal-03978017 , version 1 (01-03-2023)

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Dorines Rosario, Gholamreza Bidkhori, Sunjae Lee, Janis Bedarf, Falk Hildebrand, et al.. Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease. Cell Reports, 2021, 34 (9), pp.108807. ⟨10.1016/j.celrep.2021.108807⟩. ⟨hal-03978017⟩

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