Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Nutrients Year : 2023

Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations


Viniferin is a phenolic compound belonging to the group of stilbenoids. In particular, ε-viniferin is a dimer of resveratrol, found in many plant genders, among which grapes (Vitis vinifera) are a primary source. Due to the fact that ε-viniferin is mainly present in the woody parts of plants, their use as a source of this bioactive compound is a very interesting issue in a circular economy. Both, in vitro studies carried out in pre-adipocytes and mature adipocytes and in vivo studies addressed in mice show that ε-viniferin is able to reduce fat accumulation. Moreover, it prevents the development of some obesity co-morbidities, such as type 2 diabetes, dyslipidemias, hypertension and fatty liver. ε-viniferin can be absorbed orally, but it shows a very low bioavailability. In this scenario, further research on animal models is needed to confirm the effects reported in a great number of studies; to determine which metabolites are involved, including the main one responsible for the biological effects observed and the mechanisms that justify these effects. In a further phase, human studies should be addressed in order to use ε-viniferin as a new tool for obesity management, as a nutraceutical or to be included in functional foods.
Fichier principal
Vignette du fichier
2023_Gómez-Zorita.pdf (938.05 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY - Attribution

Dates and versions

hal-04099781 , version 1 (17-05-2023)





Saioa Gómez-Zorita, Iñaki Milton-Laskibar, Itziar Eseberri, Pauline Beaumont, Arnaud Courtois, et al.. Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations. Nutrients, 2023, 15 (4), pp.928. ⟨10.3390/nu15040928⟩. ⟨hal-04099781⟩


10 View
1 Download



Gmail Facebook X LinkedIn More