Monitoring anthelmintic resistance: from molecular markers to phenotypic assays - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Conference Papers Year : 2020

Monitoring anthelmintic resistance: from molecular markers to phenotypic assays

Cédric Neveu
Elise Courtot
Abdallah Harmache
Fabrice Guégnard
  • Function : Author
  • PersonId : 1206399
Claude L. Charvet

Abstract

The control of parasitic nematode infections in humans, livestock and companion animals is critically dependent on anthelmintic treatments. However, the indiscriminate use of anthelmintic drugs has inevitably led to the selection of resistant parasites. In this context, diagnosis tools are of particular interest to monitor the resistance spreading and refine strategies for the control of resistant parasites. In this presentation, recent advances in automated phenotypic assays performed on larval stages of the parasite will be discussed. In addition, based on the example of the imidazothiazoles/tetrahydropyrimidines anthelmintics, the identification and functional validation of molecular markers associated with resistance will be presented, opening a discussion about the advantages and limitations of the use of C. elegans as a model for parasitic species.

Domains

Parasitology
No file

Dates and versions

hal-04123852 , version 1 (09-06-2023)

Identifiers

  • HAL Id : hal-04123852 , version 1

Cite

Cédric Neveu, Elise Courtot, Abdallah Harmache, Fabrice Guégnard, Claude L. Charvet. Monitoring anthelmintic resistance: from molecular markers to phenotypic assays. 4. COMBAR Joint Working Group meeting : “Anthelmintic Resistance in Ruminants: from Research to Recommendations”, Dr Johannes Charlier, Dec 2020, online, Lithuania. ⟨hal-04123852⟩
13 View
0 Download

Share

Gmail Mastodon Facebook X LinkedIn More