Micropollutants (MP) emitted by human activities represent a threat to our health and aquatic environment. Thousands of active substances are used and go to WWTP through wastewaters. During wastewater treatment, part of the MP present in the influent are eliminated from water with sorption to sludge, volatilization and transformations. Effluents released to the environment still contain part of the MP. Here, we studied the potential impacts on Human health and aquatic environment of 261 organic MP and 25 inorganic MP at the scale of France with life cycle analysis approach. The impacts on Human health were only estimated for 94 organic and 15 inorganic MP and on aquatic environment for 88 organic and 19 inorganic MP highlighting lack of either concentration or toxicological data in literature. Some Polycyclic Aromatic Hydrocarbons and pesticides as well as As and Zn showed highest potential impacts on Human health. Some pesticides, PCB 101, βE2, Al, Fe and Cu showed highest potential impacts on aquatic environment.