Macronutrient intake during infancy and neurodevelopment in preschool children from the EDEN mother–child cohort

Background: Although the deleterious effect of micronutrient deficiency at sensitive periods on neurodevelopment is well established, the potential influence of macronutrient intake on early life neurodevelopment of healthy term infants has been seldomly studied. We aimed to explore whether macronutrient intake at 12 months was related to neurodevelopmental scores in preschool children. Methods: Analyses were based on data from the EDEN mother-child cohort. Macronutrient intake was assessed by 3-day food records at 12 months of age. Neurodevelopment was assessed at 3 years using the French version of the Ages and Stages Questionnaire (ASQ) (n=914), and at 5-6 years, using the French version of the Wechsler Preschool and Primary Scale of Intelligence-Third Edition (n=785). An association between macronutrient intake and neurodevelopmental scores were analysed by multivariable linear regression for 3-year Full Score ASQ or 5-6-year intelligence quotient scores and multivariable logistic regression for 3-year ASQ subdomains. Results: Macronutrient intake in infancy was not associated with neurodevelopmental scores in preschool children. No association was found between PUFA intake and overall neurodevelopmental scores, after accounting for multiple testing. Conclusion: In the present study, macronutrient intake at one year did not appear to influence the child's cognitive ability at 3 and 5-6 years. Further studies are needed to clarify the relationship between early fatty acid intake and neurodevelopment.

Mots clés

Nutrients Fatty acids Cognition Childhood intelligence quotient Nutrients Fatty acids Cognition Childhood intelligence quotient

Domaines

Santé publique et épidémiologie Alimentation et Nutrition

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Paper_Macronutr_Neuro_EJCNR2_Main_2023_01_06.pdf (318.03 Ko)

Paper_Macronutr_Neuro_EJCNR2_F1.pdf.pdf (52.6 Ko)

Paper_Macronutr_Neuro_EJCNR2_OSM_2023_01_06.pdf (526.32 Ko)

Paper_Macronutr_Neuro_EJCNR2_T1.pdf (117.74 Ko)

Paper_Macronutr_Neuro_EJCNR2_T2.pdf (80.26 Ko)

Paper_Macronutr_Neuro_EJCNR2_T3.pdf (90.25 Ko)

Paper_Macronutr_Neuro_EJCNR2_T4.pdf (98.6 Ko)

Paper_Macronutr_Neuro_EJCNR2_T5.pdf (109.63 Ko)

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https://hal.inrae.fr/hal-04176183

Soumis le : mercredi 2 août 2023-16:51:00

Dernière modification le : vendredi 12 janvier 2024-17:44:27

Dates et versions

hal-04176183 , version 1 (02-08-2023)

Identifiants

HAL Id : hal-04176183 , version 1
DOI : 10.1038/s41430-023-01273-z
PUBMED : 36806783
WOS : 000935540300001

Citer

Ana Rita Marinho, Daniela Correia, Jonathan Y Bernard, Barbara Heude, Carla Lopes, et al.. Macronutrient intake during infancy and neurodevelopment in preschool children from the EDEN mother–child cohort. European Journal of Clinical Nutrition, 2023, 77 (6), pp.668-676. ⟨10.1038/s41430-023-01273-z⟩. ⟨hal-04176183⟩

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