Xanthomonas bacteria cause many diseases affecting commercially important crops. Most Xanthomonas species translocate Transcription Activator-Like Effectors (TALEs) into plant cells via their type III secretion system. TALEs are a unique class of bacterial effector acting as eukaryotic transcription factors to upregulate the expression of specific plant genes called susceptibility genes (S genes) for the bacteria benefit. According to recent studies, Xanthomonas species-specific disease management techniques can be developed by manipulating the host S genes. SWEET genes are S genes targeted by Xanthomonas species, which encode for sugar transporters that are key to susceptibility in rice, cassava and citrus. Upregulation of these transporters in response to TALEs is speculated to accelerate disease development by increasing the amount of nutrients supplied to pathogens and/or by contributing to sugar signaling for disease resistance. We identified the repertoire of Xanthomonas tal genes from Xanthomonas campestris pv. campestris (Xcc), the causal agent of blackrot disease in Brassicaceae. To determine the transcriptome modifications induced by the Xcc TALEs, we did RNAseq experiments in cauliflower (Brassica oleracea). Interestingly, we demonstrated that Tal12a contributes to Xcc virulence on cauliflower, possibly by inducing the expression of BoSWEET sugar transporters. We will present our latest results on the contribution of SWEET genes to susceptibility in cauliflower.